A Preliminary Report – Paul O’Hollaren, M.D., Seattle, Washington – From the Research Department, Shadel Hospital
Describes the problem drinker, the intoxicated state, the accumulation of toxins in the system and the technique for their dispersal. The aim of the treatment is the restoration of the individual’s health, removing the craving for alcohol, and the maintenance of complete sobriety, and provides hope for many.
In a paper published in the journal Cell, David Sinclair and his colleagues describe for the first time a compound naturally made by young cells that was able to revive older cells and make them energetic and youthful again. In an experiment in mice, the team found that giving older mice a chemical called NAD for just one week made 2-year-old-mice tissue resemble that of 6-month-old mice (in human years, that would be akin to a 60-year-old’s cells becoming more like those belonging to a 20-year-old).
By Giulio Maria Pasinetti1, 2, Amanda E Bilski1, Wei Zhao1, 2 . Cell Research (2013) 23:1073-1074. doi:10.1038/cr.2013.94; published online 16 July 2013
We know that modulation of sirtuin impacts the course of several non- aggregate-forming neurodegenerative diseases, including Alzheimer’s, Huntinton’s, Parkinson’s, and more. Are the facts gleaned from animal trials sufficient to warrant entry into human clinical trials?
By Dong Liu, Robert Gharavi, Michael Pitta, Marc Gleichmann, Mark P. Mattson : Received: 17 February 2009/Accepted: 27 February 2009/Published online: 14 March 2009 Humana Press Inc. 2009
Findings demonstrate that the NAD+ bioenergetic state is critical in neurons’ survival rate during conditions of exitotoxicity and ischemia, leading to a suggestion for a potential therapy. The study also explores the impact of SIRTI enzyme activity on cell survival.
By: Ana P. Gomes, Glenn Labs for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Center for Neurosciences and Cell Biology, 3004-517 Coimbra, Portugal Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, Department of Biology, Massachusetts Institute of Technology, Paul F. Glenn Laboratory for the Science of Aging, Cambridge, MA 02139, USA
Making definite strides in turning back the clock on cellular aging in mice.
By: Journal of Orthomolecular Medicine (Year Unknown) Vol. 1, No. 3 pp.149-157
“Oral nicotinic acid therapy provides an effective biological treatment for addiction to both alcohol and opiate drugs … “There is considerable evidence that this same treatment is effective for other manifestations of the NAD deficiency disease like anorexia nervosa, early diabetes mellitus, heart failure, essential hypertension, and even the problems of predatory behavior like crime and violence.”
By: Tetsuhito FUKUSHIMA 1 Department of Hygiene & Preventive Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan [Environmental Health and Preventive Medicine 10, 3–8, January 2005]
“The possible role of niacin in the pathogenesis of Parkinson’s disease is investigated through a detailed discussion of niacin metabolism.” It wraps up with the suggestion of maize (in combination with a balance of other nutrients) as a preventive for Parkinson’s.
From [ Orthomolecular.org ]: From Vitamin B3: Niacin and Its Amide, by A. Hoffer, M.D., Ph.D.; Wilson B: The vitamin B3 therapy: The first communication to AA’s physicians (1967); A second communication to AA’s physicians (1968).
A quick history of Bill Wilson, and his positive experiences with nutritional therapy to relieve anxiety, depression, tension, and fatigue, despite medical opposition. Bill Wilson was a co-founder of Alcoholics Anonymous. The 12- Step spiritual program he helped create has been incorporated into treatment centers around the world. Unknown to many, was his belief in nutrition and its value in achieving sobriety – specifically, his promotion of Niacin (B-3).
Dr.J P VERSTER M.B. Ch., M.Med. (Psych.) PSYCHIATRIST
The author has successfully utilized the pyridine nucleotides, particularly the diphosphopyridine nucleotide, in its oxidized form, in the prevention, alleviation and removal of the acute and chronic symptoms of alcoholism.
Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, Netherlands for Integrative and Systems Physiology, School of Life Science, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland
A discussion of extensive evidence that SIRT1 can improve health and prevent age-related disease. It does not necessarily prolong life, but supports good health by maintaining mitochondrial fitness.
A nutrient-dense exploration of therapeutic approaches related to intracellular trafficking, by “improving cellular highways… and by promoting an efficient degradation of damaged organelles or toxic protein aggregates (potentiating ALP).” The hope is to translate this knowledge into more effective therapies for Parkinson’s Disease.
*S. L. BROOM1, R. MESTAYER2, E. STULLER3, D. COOK4, J. CARSON2, K. SIMONE2, P. NORRIS2, P. HOTARD2 1Dept Psychol, William Carey Univ., Hattiesburg, MS; 2Springfield Wellness Center, Springfield, LA; 3Stullerresettings, LLC; 4 ABAM.SoberMD,LLC
This pilot study retrospectively examined the anti-craving properties of NAD in a group of 60 patients. The positive results are shown in a series of graphs, demonstrating the effectiveness of the treatment.
Professor George Birkmayer, MD/PhD, developer of stabilized NADH, was the first to identify the importance of NADH in cellular development and energy transmissions for all bodily functions and organs. He founded the Menuco Corporation in 1995 and is a world-renowned biochemical researcher and is the Medical Director of the Birkmayer Institute for Parkinson’s Therapy, which has treated thousands of patients suffering from Parkinson’s disease, after having studied the biochemical connections between Parkinson’s and NADH.
Ana P. Gomes, Glenn Labs for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
The fountain of youth appears to reside in the tiny parts of our bodies. As mitochondrial function declines with the years, what initially triggers it? Even more interesting is the possibility of reversing it through boosting with NAD. Read on!
Meat contains ten times as much niacin (Vitamin B3) as fruits, vegetables, and grains. Niacin was discovered to cure pellagra, and can reduce the craving for alcohol and other substances. In working with addicts, Dr. Cleary began to see a linkage between addiction and the predatory behavior, which involves killing the prey without remorse. He states that “Better nutrition may be the way toward real peace.”